Allele/Variant

Becn1tm2.1Blev

Species
Mus musculus
Symbol
Becn1tm2.1Blev
Category
allele
Allele of gene
Becn1
Transgenic Constructs
None
Synonyms
  • Becn1F121A
  • Becn1FA
Description
A floxed neo cassette was inserted in intron 7 and an F121A mutation was created in exon 6 via homologous recombination. Cre-meditated recombination removed the neo cassette. The mutation in exon 6 disrupts binding to BCL2 resulting in constitutively high autophagy.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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