Version: 8.0.0
Date: Tue Jan 28 2025
Notch2tm2.2Ecan
MGI:6157623
Allele of Notch2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Notch2tm2.2Ecan

Species
Mus musculus
Symbol
Notch2tm2.2Ecan
Category
allele
Allele of gene
Notch2
Transgenic Constructs
None
Synonyms
  • Notch2deltaPEST
Description
A conditional by inversion (COIN) intron consisting of a lox66_SA-HA tag-IRES-Egfp-rabbit beta-globin polyA_lox71 was inserted in the antisense orientation after AAG codon encoding lysine 2384 in exon 34 via homologous recombination. The two lox sites are in reverse complementation orientation, thus cre-mediated recombination will irreversibly invert the inserted sequence. In addition an FRT flanked UBp-neomycin selection cassette was inserted after the COIN intron. Flp-mediated recombination removed the neomycin cassette. Cre-mediated recombination inverted the inserted sequence resulting in the expression of an HA-tagged truncated protein lacking the PEST domain and Egfp.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page