Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(hs653-cre/ERT2,-GFP)869Jlr
- Species
- Mus musculus
- Symbol
- Tg(hs653-cre/ERT2,-GFP)869Jlr
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- 653-CreER-IRES-GFP
- Tg(SOX14-cre/ERT2, GFP)869Jlr
- Description
- This transgene contains the human enhancer element hs653 -- which is flanked on human Chr 3 by the interleukin 20 receptor subunit beta (IL20RB) and SRY-box 14 (SOX14) loci -- followed by a mouse minimal Hsp68 promoter, the cre/ERT2 fusion gene, an internal ribosomal entry site (IRES), and a green fluorescent protein reporter gene. The fusion gene encodes Cre recombinase joined to a modified ligand-binding domain of the human estrogen receptor that preferentially binds tamoxifen or 4-hydroxytamoxifen, but not endogenous 17beta-estradiol; upon binding to tamoxifen, the cre/ERT2 protein is translocated to the nucleus.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- None
- Knock-down Targets
- None
- Regulatory Regions
- hs653