Allele/Variant

Tg(GFAP-ATXN7*92Q)2542Als

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

Gfa2-SCA7-92Q line 2,542

Description

A 2.2-kb human glial fibrillary acidic protein fragment of the promotor region drives the expression of a flag and c-myc tagged human ataxin-7 cDNA bearing 92 glutamines. Western blot analysis confirmed expression of the transgene. Immunostaining confirmed that expression is restricted to regions of the cerebellum in which Bergmann glia reside and is probably nuclear and cytosolic. This is the high expressing line.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

ATXN7 (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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