Allele/Variant

Arxtm1.1Ics

Species
Mus musculus
Symbol
Arxtm1.1Ics
Category
allele
Allele of gene
Arx
Transgenic Constructs
None
Synonyms
  • Arxdup24
  • ArxKI.ICS
Description
Exon 2 was replaced with one in which murine nucleotides 459-698 were replaced by the corresponding human sequence (amino acids 79-160) containing a 24 bp duplication in the polyalanine tract (c.428_451dup24) generating a partially humanized exon 2. A loxP-flanked neomycin resistance cassette follows the modified exon 2 and was removed via cre-mediated recombination. Western blot analysis confirmed reduced protein expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
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