Version: 8.0.0
Date: Tue Jan 28 2025
Ly6atm2.1(cre/Esr1*)Jmol
MGI:6198591
Allele of Ly6a
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Ly6atm2.1(cre/Esr1*)Jmol

Species
Mus musculus
Symbol
Ly6atm2.1(cre/Esr1*)Jmol
Category
allele
Allele of gene
Ly6a
Transgenic Constructs
Synonyms
  • Ly6aMerCreMer
Description
A cDNA encoding a MerCreMer fusion protein and an FRT-flanked neomycin cassette were recombined in-frame with the Ly6a ATG start codon (exon 2) via homologous recombination in embryonic stem (ES) cells. The MerCreMer double fusion protein incorporates a cre recombinase cDNA sequence flanked by mutated murine estrogen receptor (mer) ligand binding domains (amino acids 281-599, G525R). Resultant mice were crossed with Flpe mice to delete the neomycin cassette. Expression of Ly6a is eliminated in the targeted allele.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
per page

    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
    References
    No records match query. Try removing filters.
    Showing 0 - 0 of 0 rows
    per page