Allele/Variant

Ndc80em1(IMPC)J

Species
Mus musculus
Symbol
Ndc80em1(IMPC)J
Category
allele
Allele of gene
Ndc80
Transgenic Constructs
None
Synonyms
  • Ndc80-
Description
This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ATAGGTAAGATAAGAACCAT and GTATAAGAGTATTTAAGGAG, which resulted in a 364 bp deletion beginning at Chromosome 17 position 71,518,724 bp and ending after 71,519,087 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000137722 (exon 6) and 261 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 159 and early truncation 4 amino acids later.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
embryonic lethality prior to organogenesisMGI
embryonic lethality prior to organogenesis, complete penetranceMGI
failure of blastocyst to hatch from the zona pellucidaMGI
preweaning lethality, complete penetranceMGI
Showing 1 - 4 of 4 rows
per page

Disease Associations

No data available