Allele/Variant

Prr5em1(IMPC)J

Species
Mus musculus
Symbol
Prr5em1(IMPC)J
Category
allele
Allele of gene
Prr5
Transgenic Constructs
None
Synonyms
None
Description
This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CTAGCCCTCACCAGTACTGT and AGCCCTCCTGGGCTCCCAAG, which resulted in a 481 bp deletion beginning at Chromosome 15 position 84,693,421 bp and ending after 84,693,901 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000622449 and ENSMUSE00000622448 (exons 3 and 4) and 374 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 73 and early truncation 16 amino acids later. There is also a single bp (A) insertion at the deletion site.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations