Version: 8.0.0
Date: Tue Jan 28 2025
Col10a1tm2.1Rpbh
MGI:6259993
Allele of Col10a1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Col10a1tm2.1Rpbh

Species
Mus musculus
Symbol
Col10a1tm2.1Rpbh
Category
allele
Allele of gene
Col10a1
Transgenic Constructs
None
Synonyms
  • Col10a1 p.Tyr632stop
Description
A C to G single-base pair substitution that changes the Tyrosine 632 codon (TAC) to a stop codon (TAG; Y632X) was introduced by site-directed mutagenesis in exon 3. A neomycin selection cassette flanked by FRT sites was inserted 199 bp upstream of the native stop codon into a non-conserved region of 3-UTR in exon 2 which is devoid of potential microRNA-binding sites. The selection cassette was excised via flp-mediated recombination. mRNA is stable and mRNA levels are similar to wild-type levels.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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