Nrf1^{tm1c(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Nrf1^{tm1c(KOMP)Wtsi}

Category

allele

Allele of gene

Nrf1

Transgenic Constructs

None

Synonyms

• Nrf1^flox

Description

The L1L2_gt1 cassette was inserted at position 30094851 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 30095743. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations