Allele/Variant

Nmnat1tm1d(EUCOMM)Wtsi

Species
Mus musculus
Symbol
Nmnat1tm1d(EUCOMM)Wtsi
Category
allele
Allele of gene
Nmnat1
Transgenic Constructs
None
Synonyms
  • Nmnat1-
Description
The L1L2_gt1 cassette was inserted at position 149557403 of Chromosome 4 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 149558354. The critical exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Subsequent cre-mediated recombination deleted exon 2 and resulted in a knockout mouse.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations