Allele/Variant

Comttm1.1Tunb

Species
Mus musculus
Symbol
Comttm1.1Tunb
Category
allele
Allele of gene
Comt
Transgenic Constructs
None
Synonyms
  • COMT-Met
Description
The targeting was designed to alter the DNA sequence of codon 148 in exon 3 from CTA to ATG creating a leucine-to-methionine amino acids substitution (L148M) and insert a loxP-flanked PGK-neo selection cassette in intron 3. The substitution is analogous to the human Val<158>Met mutation. Cre-mediated recombination removed the floxed neo cassette. Immunoblot analysis indicats that both soluble and membrane bound protein isoforms are reduced in all brain regions.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations