Allele/Variant

Tg(Myh6-Kcnj8*/EGFP)1Wco

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

alpha-MHC-Kir6.1-AAA-eGFP
Kir6.1-AAA

Description

The alpha-myosin heavy chain promoter drives cardiac-specific expression of a dominant negative rat Kcnj8 mutant, in which the subunit pore region was mutated from glycine-phenylalanine-glycine to three alanines, with a COOH-terminal enhanced green fluorescent protein. RT-PCR and Western blotting confirmed expression of the transgene specifically in the heart. Several lines were made but only one was further analyzed.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

Kcnj8 (Rno)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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