Nf1^{tm1d(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Nf1^{tm1d(KOMP)Wtsi}

Category

allele

Allele of gene

Nf1

Transgenic Constructs

None

Synonyms

• Nf1^delta4

Description

The L1L2_gt0 cassette was inserted at position 79280528 of Chromosome 11 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon at position 79281558. The critical exon 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. The knockout allele was created by deletion exon 4 through subsequent cre-mediated recombination.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations