Allele/Variant

Tg(CAG-Ncoa6)84Hwl

Species
Mus musculus
Symbol
Tg(CAG-Ncoa6)84Hwl
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • DN1
Description
This transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929 under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This Ncoa6 fragment encompasses the N-terminal LXXLL motif (called DN1) and has a strong dominant negative effect on transactivation by retinoid and other nuclear receptors. This line shows transgene expression in the eye, heart, and brain.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
  • Ncoa6
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations