ENU-induced T to A transversion at base pair 20,582,939 (v38) on chromosome 18, or base pair 24,866 in the GenBank genomic region NC_000084 encoding Dsg2. The mutation corresponds to residue 1,057 in the mRNA sequence NM_007883 within exon 8 of 15 total exons. The mutation results in substitution of tyrosine 282 for a premature stop codon (Y282*) in the DSG2 protein.