ENU-induced A to T transversion at base pair 158,956,645 (v38) on chromosome 1, or base pair 23,883 in the GenBank genomic region NC_000067. The mutation corresponds to residue 794 in the mRNA sequence NM_001085376 within exon 1 of 22 total exons. The mutation results in a tyrosine to phenylalanine substitution at position 265 (Y265F) in the PAPP-A2 protein.