Allele/Variant

Depdc1aem1(IMPC)J

Species
Mus musculus
Symbol
Depdc1aem1(IMPC)J
Category
allele
Allele of gene
Depdc1a
Transgenic Constructs
None
Synonyms
None
Description
This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TAGTTTGTACTCAAACTGAA and TTTTCAAACCTAGTAACCAA, which resulted in a 750 bp deletion beginning at Chromosome 3 position 159,515,449 bp and ending after 159,516,198 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000399599 and ENSMUSE00000361974 (exons 4 and 5) and 497 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 157 and early truncation 10 amino acids later.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations