Allele/Variant

Kirrel2tm2c(KOMP)Wtsi

Species
Mus musculus
Symbol
Kirrel2tm2c(KOMP)Wtsi
Category
allele
Allele of gene
Kirrel2
Transgenic Constructs
None
Synonyms
  • Kirrel2lox
Description
The L1L2_Bact_P cassette was inserted at position 30154397 of Chromosome 7 upstream of the critical exons 3 and 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 4 at position 30155529. Exons 3 and 4 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving exons 3 and 4 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal olfactory bulb glomerular layer morphologyMGI
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Disease Associations

No data available