Allele/Variant

Tg(Prnp-MAPT*P301S)50Hiw

Species

Mus musculus

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

TPR50

Description

The mouse prion promoter drives the expression of the longest human tau (MAPT) isoform (4R2N) in which proline is replaced by a serine at amino acid position 301 of the protein (P301S). Seven lines were established (16, 50, 56, 72, 82, 96, and 100). Line 50 is the highest expressing line. Western blot analysis confirmed increased expression in the hippocampus and showed that human tau is phosphorylated at T181, S202/T205, S214, S262, and S396.

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

MAPT (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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