Tg(Myoc*Y423H)#Sit

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Species

Mus musculus

Symbol

Tg(Myoc*Y423H)#Sit

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

None

Description

This transgene consists of BAC DNA 16652 containing the full-length mouse myocilin with a Tyr423His point mutation (T to C in codon 423) as well as 20 and 85.5 kb of the 5'-flanking and 3'-flanking sequences. This mutation corresponds to the severe glaucoma-causing Tyr437His mutation in human. Several lines were generated, however one line containing 2-3 copies of the mutated gene was used for analysis. The pound symbol (#) is used when line is not specified.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations