Dok6^em1(IMPC)J

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Species

Mus musculus

Symbol

Dok6^em1(IMPC)J

Category

allele

Allele of gene

Dok6

Transgenic Constructs

None

Synonyms

None

Description

This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences AATTTCCTCAAGCTGTAGAT and GGCCAGTTATCACTACCCTA, which resulted in a 294 bp deletion beginning at Chromosome 18 position 89,559,906 bp and ending after 89,560,199 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000658810 (exon 3) and 179 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 58 and early truncation 19 amino acids later. There is a 5 bp insertion (GGTAG) 106 bp before the deletion.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations