Allele/Variant

Tg(Prnp-HTT*82Q)61Gschi

Species
Mus musculus
Symbol
Tg(Prnp-HTT*82Q)61Gschi
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • NLS-N171-82Q
Description
The first 171 amino acids of human huntingtin with an expanded glutamine tract of 82 glutamines fused at the N-terminus to the nuclear localization signal sequence from atrophin-1 (first 30 amino acids) is under the control of the mouse prion protein promoter. Western blot and immunohistochemical analyses confirmed that the huntingtin fragments accumulate in nuclear, but not cytoplasmic, compartments.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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