Allele/Variant

Tg(Myh6*/tetO-Hspb8*K141N)#Atsa

Species
Mus musculus
Symbol
Tg(Myh6*/tetO-Hspb8*K141N)#Atsa
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
None
Description
The coding region of mouse heat shock protein 8 with the lysine to asparagine missense mutation at amino acid 141 (K141N) with an N-terminal HA tag was inserted into an MHCminTetO-promotor construct. The expression of the construct was driven by a mouse alpha-myosin heavy chain promoter with 3 altered GATA sites and 2 altered thyroid-like response elements for maintaining low levels of cardiac-specific expression, under the control of a tetracycline operator.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Phenotype
Annotation details
Source
References
abnormal heart morphologyMGI
abnormal oxidative phosphorylationMGI
amyloid beta depositsMGI
cardiac fibrosisMGI
cardiac hypertrophyMGI
cardiomyopathyMGI
decreased cardiac muscle contractilityMGI
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Disease Associations

No data available