Allele/Variant

Tg(Vav1-Asxl1*Y588X)#Fcy

Species
Mus musculus
Symbol
Tg(Vav1-Asxl1*Y588X)#Fcy
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Asxl1Y588XTg
Description
The entire coding region of mouse Asxl1 cDNA with a TAC to TGA change resulting in a stop codon mutation on the Y588 site with a FLAG tag is under the control of the Vav1 promoter. Y558X in the mouse corresponds to human Y591X which is the most frequent nonsense mutation type in patients with malignant myeloid diseases. Western blot analysis confirmed the expression of a truncated protein. Five lines were generated, I through V. The pound symbol (#) is used when no line is specified and/or lines are pooled. J:257690 reports pooled data from lines I and II.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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