Allele/Variant

Tg(Thy1-APP*Swe*Ind)fAccu

Species
Mus musculus
Symbol
Tg(Thy1-APP*Swe*Ind)fAccu
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • McGill-Thy1-APP Tg
Description
The murine thymocyte antigen promotor (Thy1) drives the expression of the human APP (APP-751) cDNA bearing the Swedish double mutation K670N and M671L and the Indiana mutation V717F primarily in pyramidal neurons of the telencephalon and starting postnatally. Transgene copy number as assessed by Southern blotting is estimated to be about 20. Western blot analysis confirmed overexpression of the transgene in the hippocampus and cortex. Mice express on average 2-fold higher levels of amyloid beta42 than of amyloid beta40 in both cortex and hippocampus.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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