Allele/Variant

Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz

Species
Mus musculus
Symbol
Tg(tetO-GFP,-APOL1*S342G*I384M)#Susz
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • TRE-APOL1-G1
Description
The human APOL1 kidney disease risk variant G1 contains a double missense mutation resulting in a serine to glycine change at amino acid 342 (S342G) and isoleucine to methionine change at amino acid 384 (I384M) and is able to lyse T. brucei rhodesiense, is under the control of the tetracycline responsive promoter element. The pound (#) sign is used when the line number is not specified or lines are pooled. The gene is only expressed in a tetracycline/doxycycline controllable manner when mice carrying this allele also carry a tTA or rtTA allele.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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