Allele/Variant

Arpp19tm1d(KOMP)Mbp

Species
Mus musculus
Symbol
Arpp19tm1d(KOMP)Mbp
Category
allele
Allele of gene
Arpp19
Transgenic Constructs
None
Synonyms
  • Arpp19delta
Description
The L1L2_Bact_P cassette was inserted at position 74963458 of Chromosome 9 upstream of the critical exon 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 74965535. The critical exon 4 is thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

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