Ankrd31^em1Atot

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Species

Mus musculus

Symbol

Ankrd31^em1Atot

Category

allele

Allele of gene

Ankrd31

Transgenic Constructs

None

Synonyms

• Ankrd3^1mut1
• Ankrd31^-

Show All 3

Description

CRIPSR/Cas9 genome editing created a 5 bp deletion as well as an insertion of four A residues in exon 6. This results in a frameshift after the 134th codon in the longest open reading frame, and is predicted to severely truncate the encoded protein. Immunoprecipitation-Western blot analysis of testis extracts and immunofluorescence in fixed gonadal samples confirmed that domains that are C-terminal to the frameshift position are not produced in homozygous mutant meiocytes.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations