Allele/Variant

Tg(Thy1-APP*)2Tbay

Species
Mus musculus
Symbol
Tg(Thy1-APP*)2Tbay
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(Thy1-Trh/Abeta*)2Tbay
  • Tg4-42
Description
The 7.2kb kb Tg4-42 transgene is designed with the Thy1 promoter driving expression of human Abeta 4-42 fused to a murine thyrotropin releasing hormone signal peptide. Transgenic mice express an N-truncated Abeta 4-42< (amino acids 4-42), a peptide shown to enhance Abeta aggregation in the brains of Alzheimer's disease (AD) patients. Founder line 2 has the highest expression of the transgene and sontains more than 20 copies in head-to-tail orientation, with the last transgene in reverse orientation.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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