Coa8^em1Zev

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Species

Mus musculus

Symbol

Coa8^em1Zev

Category

allele

Allele of gene

Coa8

Transgenic Constructs

None

Synonyms

None

Description

The molecular lesion, created using CRISPR/Cas9 technology, is a substitution of an A with a TG doublet in exon 2 (c.164delAinsTG, mRNA sequence GenBank NM_026511), which generates a frameshift resulting in a truncated protein (p.Asp55Valfs*20). Skeletal muscle and liver mRNA levels were reduced to 25% and 50%, respectively.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations