Cad^{tm1c(KOMP)Wtsi}

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Species

Mus musculus

Symbol

Cad^{tm1c(KOMP)Wtsi}

Category

allele

Allele of gene

Cad

Transgenic Constructs

None

Synonyms

• Cad^fl

Description

The L1L2_Bact_P cassette was inserted at position 31214943 of Chromosome 5 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 31215660. The critical exon 3 is thus flanked by loxP sites. A conditional ready (floxed) allele is created by flp recombinase expression to remove the reporter and selection cassette, leaving exon 3 floxed.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations