Pcx^{tm1c(EUCOMM)Wtsi}

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Species

Mus musculus

Symbol

Pcx^{tm1c(EUCOMM)Wtsi}

Category

allele

Allele of gene

Pcx

Transgenic Constructs

None

Synonyms

• Pcx^f

Description

The L1L2_Pgk_P cassette was inserted at position 4657097 of Chromosome 19 upstream of the critical exon10 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 10 at position 4657983. The critical exon 10 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations