Allele/Variant

Trim35em1(IMPC)J

Species
Mus musculus
Symbol
Trim35em1(IMPC)J
Category
allele
Allele of gene
Trim35
Transgenic Constructs
None
Synonyms
None
Description
This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCTTTGGGACGCCCCAGCTG and GAGGGTCGATACTCTCCACA, which resulted in a 3327 bp deletion beginning at Chromosome 14 position 66,303,946 bp and ending after 66,307,272 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000123182, ENSMUSE00000123182, ENSMUSE00000123176 (exons 2, 3 and 4) and 2977 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 161 and early truncation 36 amino acids later.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal auditory brainstem responseMGI
increased total body fat amountMGI
preweaning lethality, incomplete penetranceMGI
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Disease Associations

No data available