Allele/Variant

Gpr63em2Rstot

Species
Mus musculus
Symbol
Gpr63em2Rstot
Category
allele
Allele of gene
Gpr63
Transgenic Constructs
None
Synonyms
  • Gpr63Del
Description
Using CRISPR/Cas9 technology, an 8 bp deletion (ACACAAGT) was created in the FVB strain, resulting in a frameshift and a premature stop codon. The resulting peptide lacks the last 21 wild-type amino-acids and gains five new amino-acids before premature termination, thus disrupting both an ER retention signal and an RGS3 PDZ binding motif. The deletion encompasses SNP rs13477613 (G>T, the last T in the deletion), which is specific to FVB and A/J.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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