Yif1b^tm1.2Ics

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Species

Mus musculus

Symbol

Yif1b^tm1.2Ics

Category

allele

Allele of gene

Yif1b

Transgenic Constructs

None

Synonyms

• Yif1B KO

Description

A FRT-loxP-neo-FRT-LoxP cassette was inserted upstream exon 2 and a single loxP site was inserted between exon 5 and 6. The frt-flanked neomycin cassette was removed by FLP-mediated recombination, followed by cre-mediated recombination in the germline, removing exons 2-5. Western blot analysis confirmed the complete absence of protein expression in primary cultures of hippocampal neurons derived from E18 homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations