Version: 8.0.0
Date: Tue Jan 28 2025
Asah1tm1.2Geno
MGI:6401408
Allele of Asah1
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Asah1tm1.2Geno

Species
Mus musculus
Symbol
Asah1tm1.2Geno
Category
allele
Allele of gene
Asah1
Transgenic Constructs
None
Synonyms
  • Asah1tmEx1
Description
Exon 1, encoding the enzymes signal peptide, was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted and removed via Flp-mediated recombination. Exon 1 was deleted via cre-mediated recombination in the germline. Removal of the signal peptide disrupts lysosomal targeting of the enzyme. Mice exhibit reduced ceramidase activity in liver, spleen, thymus, and bone marrow.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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