Allele/Variant

Mapttm1.1(MAPT)Tcs

Species
Mus musculus
Symbol
Mapttm1.1(MAPT)Tcs
Category
allele
Allele of gene
Mapt
Transgenic Constructs
None
Synonyms
  • hTau-KI
Description
The human MAPT sequence from exon 1 to exon 14 (NCBI Reference Sequence: NG_007398 with H2 haplotype) and a loxP/FRT flanked neomycin resistance gene replaced the entire genomic sequence (from exon 1 to exon 14) of murine Mapt via homologous recombination. Cre-mediated recombination removed the neomycin gene. Western blot analysis confirmed the expression of all human tau isoforms.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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