Gcn1^em1Itohk

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Species

Mus musculus

Symbol

Gcn1^em1Itohk

Category

allele

Allele of gene

Gcn1

Transgenic Constructs

None

Synonyms

• Gcn1^-

Description

CRISPR/Cas9 technology was used to induce double-strand breaks within introns 1 and 2 and excise exon 2, resulting in a frameshift and premature stop codon in exon 3. Homozygous mutant mice only express a short form of the protein, consisting of the N-terminus 12 amino acids and lacking the eEF3-like domain and RWD binding domain.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations