Tg(Thy1/THY1)T12Gsv

---

Species

Mus musculus

Symbol

Tg(Thy1/THY1)T12Gsv

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

• T12

Description

This transgene consists of a hybrid Thy1 gene in which a 5.7 kb EcoRI-ApaI mouse Thy1^a (Thy1.1) gene fragment containing the first 4 exons (including exons 1a and 1b) and part of exon 4 are fused to a 3.4 kb ApaI-EcoRI human THY1 DNA sequence containing the remaining noncoding part of exon 4 plus 3' human flanking sequence. Four lines were generated; T6, T9, T11, and T12. The T12 line contains multiple copies of the transgene and expresses about 6-10x the normal level of Thy1 in the brain. The mature protein resulting from this transgene is completely Thy1^a. High levels of hybrid transgene expression is seen in glomerular podocytes.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations