Allele/Variant

Bicralem1(IMPC)J

Species
Mus musculus
Symbol
Bicralem1(IMPC)J
Category
allele
Allele of gene
Bicral
Transgenic Constructs
None
Synonyms
None
Description
This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences ACCTTGTGACTGACAGGAGA and ATTTTTAGCTCACCAAGCAA, which resulted in a 532 bp deletion beginning at Chromosome 17 position 46,829,784 bp and ending after 46,830,315 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000424961, ENSMUSE00000424956 (exons 2,3) and 414 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 14 and early truncation 10 amino acids later.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal bone structureMGI
abnormal retina morphologyMGI
decreased bone mineral contentMGI
decreased bone mineral densityMGI
decreased lean body massMGI
decreased prepulse inhibitionMGI
increased blood urea nitrogen levelMGI
increased mean corpuscular hemoglobinMGI
increased mean corpuscular volumeMGI
increased startle reflexMGI
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Disease Associations

No data available