Allele/Variant

Adam28tm1.2Dica

Species
Mus musculus
Symbol
Adam28tm1.2Dica
Category
allele
Allele of gene
Adam28
Transgenic Constructs
None
Synonyms
  • ADAM28 KO
Description
A loxP site was inserted into intron 1 and an FRT site flankled neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination and floxed exon 2 was deleted through subsequent cre-mediated recombination.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal alpha-beta T cell morphologyMGI
abnormal lymphocyte morphologyMGI
decreased CD8-positive, alpha-beta T cell numberMGI
increased incidence of induced tumorsMGI
increased susceptibility to induced morbidity/mortalityMGI
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Disease Associations

No data available