Aig1^em1Sagh

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Species

Mus musculus

Symbol

Aig1^em1Sagh

Category

allele

Allele of gene

Aig1

Transgenic Constructs

None

Synonyms

None

Description

CRISPR/cas9-mediated recombination created a 5 bp deletion (CTGTG) followed by a 1 bp (A) insertion in exon 1 upstream of the catalytic threonine (T43) resulting in a frameshift mutation and premature stop codon upstream of the catalytic threonine. Western blot analysis confirmed the absence of expression in brains from homozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations