Allele/Variant

Tg(Myh6-JUP*)1Dpju

Species
Mus musculus
Symbol
Tg(Myh6-JUP*)1Dpju
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • JUP2157del2
Description
The human plakoglobin cDNA with a 2 bp deletion at nucleotides 2157 and 2158 is under the control of the cardiac-specific mouse alpha-myosin heavy chain promoter. This 2 bp deletion is seen in individuals with Naxos disease. Four lines were generated but only one founder line was propagated in which expression of the exogenous truncated protein is at roughly equivalent levels to expression of the wild-type endogenous mouse protein.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations