Allele/Variant

Gsg1ltm1.2Tern

Species
Mus musculus
Symbol
Gsg1ltm1.2Tern
Category
allele
Allele of gene
Gsg1l
Transgenic Constructs
None
Synonyms
  • GSG1L-
Description
A loxP site was inserted into intron 3 and the following elements into intron 4: an FRT site, a second loxP site, engrailed homeobox 2 (en2) intron and splice acceptor sequences, IRES sequence, the tdTomato red fluorescent protein gene with sequence for a C-terminal HA tag, poly(A) signal sequence, a neomycin resistance gene cassette, a second FRT site and a third loxP site. The sequence between the FRT sites (RFP and neo cassettes) were removed through subsequent flp-mediated recombination. Exon 4 was then deleted through cre-mediated recombination.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal action potential
MGI
abnormal behavior
MGI
abnormal excitatory postsynaptic currents
MGI
abnormal miniature excitatory postsynaptic currents
MGI
abnormal response to novel object
MGI
abnormal synaptic transmission
MGI
increased excitatory postsynaptic current amplitude
MGI
increased susceptibility to pharmacologically induced seizures
MGI
short excitatory postsynaptic current decay time
MGI
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Disease Associations

No data available