Prdm9^em3Kpgn

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Species

Mus musculus

Symbol

Prdm9^em3Kpgn

Category

allele

Allele of gene

Prdm9

Transgenic Constructs

None

Synonyms

• Prdm9^EK

Description

Using CRISPR/Cas9 technology, a G-to-A substitution (C-to-T on forward strand) was created in glutamic acid codon 360 (initially reported as 365) to change it to a lysine codom (p.E360K). The mutation is located in the PR/SET domain and leads to the loss of most of the enzyme's histone methyltransferase activity. As this allele was created in the C57BL/6 strain, it is based on the Prdm9^dom2 allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations