Allele/Variant

Gt(ROSA)26Sortm1.1(Alb-PCSK9)Mby

Species
Mus musculus
Symbol
Gt(ROSA)26Sortm1.1(Alb-PCSK9)Mby
Category
allele
Allele of gene
Gt(ROSA)26Sor
Transgenic Constructs
Synonyms
  • hPCSK9-KI
Description
A targeting vector, containing human PCSK9 cDNA under the control of a 2.34 kb mouse albumin promoter/enhancer and a floxed cassette containing cre recombinase cDNA under the control of a 698 bp testis-specific angiotensin converting enzyme promotor and neomycin phosphotransferase selection marker driven by the pol II promoter, was inserted into the endogenous locus. Flp-mediated recombination removed the floxed cre and neo cassette.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations