Nlrc4^em2Vnce

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Species

Mus musculus

Symbol

Nlrc4^em2Vnce

Category

allele

Allele of gene

Nlrc4

Transgenic Constructs

None

Synonyms

• Nlrc4^{em2(S533A)Vnce}
• Nlrc4^S533A

Description

Serine codon 533 (TCA) was targeted with an sgRNA (targeting CTCTGGAGGCAGGAATCAAT) and ssODN templates using CRISPR/Cas9 technology, changing it to alanine codon GCA (p.S533A). This mutation renders the encoded peptide nonphosphorylatable at this residue. Western blot experiments confirmed the expression of peptides from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations