Allele/Variant

Dhddsem1Sjpi

Species
Mus musculus
Symbol
Dhddsem1Sjpi
Category
allele
Allele of gene
Dhdds
Transgenic Constructs
None
Synonyms
  • DhddsK42E
Description
A single A-to-G mutation was introduced to change codon 42 from lysine (AAG) to glutamic acid (GAG) (p.K42E), using a gRNA (targeting TCGCTATGCCAAGAAGTGTCAGG) and an ssODN template with CRISPR/Cas9 technology. The mutation mimics one associated with an autosomal recessive form of retinitis pigmentosa (RP59) in humans.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations