Allele/Variant

Tmc6tm1.1Les

Species
Mus musculus
Symbol
Tmc6tm1.1Les
Category
allele
Allele of gene
Tmc6
Transgenic Constructs
None
Synonyms
  • Tmc6delta
Description
A 1.6-kb fragment containing exons 6-8 was replaced with a nuclear localization signal and LacZ reporter gene, the Engrailed-2 intron and splice acceptor site (En-2/SA), and an internal ribosome entry site followed by a loxP-flanked phosphoglycerine kinase (PGK)-neomycin resistance gene. The loxP-flanked PGK-neomycin resistance gene was removed via Cre-mediated recombination in the germline. Western blot analysis using a polyclonal anti-TMC6 antibody confirmed the complete absence of protein expression in cell lysates from homozygous mutant thymocytes.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations